Global Foot-and-Mouth Disease Research Alliance
G F R A Research Alliance

2019 GFRA Scientific Meeting

Bangkok, Thailand
October 29 - 31, 2019


Opening Session

FMD status in South-East Asia, China and Mongolia
Ronello Abila, OIE

The global epidemiological situation of FMD
Anna Ludi, WRL

Global vaccine security and FMD
Keith Sumption, EuFMD

Progress of the global FMD control strategy
Samia Metwally, FAO


Session 1

Low protection with an A/Asia/G-VII lineage FMDV emergency vaccine against an FMDV A/Asia/Iran-05 lineage virus challenge
P. Eblé

Challenges in FMDV strain selection as an input to attain broad vaccine crossprotection
I. Bergmann

Protective capacity of FMD South American vaccine strains O1-Campos, A24 and A2001 against southeast Asian viruses of currently circulating topotypes
V. Malirat

Evaluation of FMDV serotype-O with improved thermostability as a vaccine candidate
B. Sreenivasa


Session 2

Session 3

FMD vaccine failures in the field
Dachrit Nilubol, Chulalongkorn University

An overview of 146S-specific llama single-domain antibody fragments for use in
M. Harmsen

Construction of a recombinant Ab phage display library derived from the immune
P. Opperman

Reduction of Agpath reagent used in FMDV real-time TaqMan assay
N. Walker

Viral particles prepared by size exclusion chromatography can be used as coating material for serological assays
C. Turco


Session 4

Towards improved foot-and-mouth disease vaccines by
Artur Summerfield

Ripk3 restricted FMDV infection via necroptosis-independent inflammation
X. Qin

Viral determinants of FMDV A/Arg/01 virulence in adult mice
M. Gismondi

Comparison of the adaptive immune responses induced by FMD-vaccines
M. Miraglia

The pathogenesis of simultaneous and serial FMDV coinfections in cattle
C. Stenfeldt


Session 5

Serological assays used to measure vaccine-induced responses against FMDV
A. Capozzo

Understanding serotypic cross-reactivity of antibody ELISAS and the impact on
A. Ludi

In-vitro vaccine-matching for FMDV: does bovine vaccinal sera (BSV) impact upon
J. Senawi

Sero-surveillance of FMD in wild boars in Korea
C. Lee


Session 6

FMDV undermines the host antiviral response by cleavage of key
Margarita Saiz, CBMSO-CSIC

Deep sequencing of FMDV reveals association between vaccination, population
I. Fish

Single point mutation of FMDV L-pro affects deisgylation and modulates the host innate immune response
G. Medina

Sec62 negatively regulates FMDV replication by up-regulating IRE1a�RIG-Imediated antiviral response
H. Guo

STING-mediated integrated stress response to FMDV infection
R. Zhang


Session 7

FMD vaccine platform: formulations for safe and DIVA-compatible FMD vaccines
J. Hardham

Baculovirus-induced fast-acting innate immunity as an antiviral strategy against FMDV
G. Molina

Re-establishment of FMD vaccine production capacity in South Africa:
F. Peta

FMD vaccines for Eastern Africa Initiative
J. Salt


Session 8

Identification of RNA packaging signals in the genome of FMDV
T. Tuthill

Molecular features of the integrin receptor and its interaction with the FMDV, an

RNA secondary structure variation of CRE of FMDV is associated with host infection sensitivity
J. Cheong

Antiviral efficacy of short hairpin RNAs and artificial microRNAs targeting FMDV 3D
M. Gismondi


Session 9

Genetic basis of the antigenic variation of the FMD virus during persistent infection in naturally infected cattle and Asian buffalo
J. Biswal

A new topical therapy for FMD addresses animal welfare and other issues
P. Windsor

Experimental infection of goats with FMDV SAT-1 serotype: their role in disease
P. Mutowembwa


Session 10

The FMD and its control in China
Y. Li, The Chinese/OIE Reference Laboratory for FMD

Our challenge is to deliver effective biosecurity in FMD endemic countries in
I. MacPhillamy

Serological epidemiology of FMD in sedentary mixed-species herds in Adamawa,
S. Lendzele

Estimation of R0 for FMDV from surveillance data in endemic settings
A. Dekker

Interaction of temperature and humidity on stability of FMD virus serotype O
N. Singanallur

Livestock mobility and the implications for endemic FMD spread and control in East Africa
D. Ekwem

Updating parameters for modeling infectiousness of FMDV in pigs
J. Arzt